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Research |
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Experience
• Research Professional Associate in the Section of Cardiothoracic Surgery Aug 06 – Sep 07
Dept. of Surgery, University of Chicago Hospitals
Roles – Surgical Procedures: Aortic banding in mouse, langendorff perfusion, pacing, catheterizations,
rabbit thoracotomy
– Primary Cultures: Isolation and culture of adult human cardiac myocytes, adult rabbit cardiac myocytes and neonatal rat cardiac myocytes
– Other: study of biochemical markers of cardiac hypertrophy, cardiac specific microarray, designing experiments, analyzing results, presentation and participation in various international scientific meetings.
• Research Assistant in the Section of Cell and Tissue Engineering Jan 01 – July 06
Dept. of Bioengineering, University of Illinois at Chicago
Roles – Primary Cultures: Isolation and culture of human umbilical vein endothelial cells, bone cells
– Biomechanics: Exposing cells to laminar fluid shear stress and ultrasound, designing of ultrasound exposing device, fixing and staining cells, morphological analysis, spectrum analysis of quantum dots
– Other: Preparing manuscripts, designing experiments and analyzing results, teaching graduate and undergraduate students, presenting research findings in major research conferences.
• Research Assistant in the
Section of Cardiology
Aug
00 - Dec 00
Dept. of Medicine, University of Illinois at Chicago
Roles – Managing and troubleshooting of the home health monitoring system
– Data mining and modeling using cardiac failure patient’s clinical data.
• Resident Intern in Medicine, Surgery, Gynecology and sub specialties May 98 - Apr 99
Pt. BDS Post Graduate Institute of Medical Sciences Rohtak, India
Roles – Performing advanced life saving procedures, supervise peers
– Clinical patient cares, patient management and discharges, weekly outpatient follows ups
– Emergency room evaluation, management of cardiac and other intensive care patients.
Education
·
Doctorate
of Philosophy (PhD) in Bioengineering (Aug 2000 – July 2006), GPA
3.30/4.00
University of Illinois at Chicago, Chicago, IL
·
Bachelor of Medicine and Bachelor of Surgery
(equivalent to MD) (Aug 1993 – Apr 1999)
Post Graduate Institute of Medical Sciences, Rohtak, India
Laboratory
Skills
· Animal survival surgeries
· Isolation of various primary cell cultures, cell-line culture and maintenance
· Exposing cells to biomechanical forces, DNA, RNA, protein isolation and sub-cellular fractionation
· Northern analysis, western analysis, ELISA, real-time and conventional RT-PCR
· Bacteria culture and cloning, transfection
· Microarray analysis
· Preparation of quantum dots, spectrum analysis of q-dots
· Immunohistochemistry, cell staining and imaging
· Cryopreservation of tissue, sectioning and fixing tissue
· Modeling of biological signals, data mining and telemedicine
· Statistical analysis, ANOVA, K-S test, student t-test, regression
Clinical Publications
· Sumit Narang, Amit Banerjee, D K Satsangi, M Abid Geelani, Vikas Saini. “Early and Midterm Results in Patients With Tetralogy of Fallot With Hypoplastic Pulmonary Annulus Using Transannular Patch Versus Valved Conduits.” Journal of American College of Cardiology, Vol. 51, Issue 10, March 2008, A274, 1020-96.
· Sumit Narang, Amit Banerjee, D K Satsangi, M Abid Geelani, Vikas Saini. “Surgical Therapy Versus Slow Thrombolytic Therapy and Fast Thrombolytic Therapy in Patients With Prosthetic Valve Thrombosis.” Journal of American College of Cardiology, Vol. 51, Issue 10, March 2008, A275, 1034-95.
Molecular
Biology Publications
· McCormick, S M; Saini, V; Royston, T J. “Synergistic Effects of Low Intensity Pulsed Ultrasound and Shear Stress on Nitric Oxide.” Transactions of Orthopedic Research Society, Vol. 32, 2007, p 1300.
- Vikas Saini, Susan M. McCormick and Thomas J. Royston “Ultrasound and Fluid Shear Stress Synergistically Increase NO Levels.”Under peer review, Bone, 2007.
· McCormick, S M; Saini, V; Yazicioglu, Y; Royston, T J. “Pulsed Ultrasound and Shear Stress Interact in the Regulation of PGE2 and PGHS-2 in MLO-Y4 Cells.” Transactions of Biomedical Engineering Society, Chicago, IL (10/11 – 14, 2006, 1206).
- Vikas Saini “Pulsed
Ultrasound and Shear Stress Interact in Their Regulation of Bone Cell
Morphology and Function.” PhD
Thesis, University of Illinois at Chicago. July 2006, US Copyright TX0006473629.
· Saini, V; McCormick, S M; Yazicioglu, Y; Demou, Z N; Royston, T J. “Interdependence of Low Intensity Pulsed Ultrasound and Laminar Fluid Shear Stress Effects on SaOS-2 Cell Morphology and BMP-4 Expression.” Transactions of Orthopedic Research Society, Vol. 31, 2006, p 1018.
· Susan M. McCormick, Vikas Saini, Yigit Yazicioglu, Zoe N. Demou, Thomas J. Royston. “Interdependence of Pulsed Ultrasound and Shear Stress Effects on Cell Morphology and Gene Expression.” Annals of BioMedical Engineering. Vol. 34, No. 3, March 2006, p 436-445.
· Vikas Saini, Susan M McCormick. “Low Intensity Pulsed Ultrasound Modulates the Effects of Laminar Fluid Shear Stress on Cell Morphology and Gene Expression.” Sigma Xi Research Forum at UIC (4/7, 2005, Session III).
· V. Saini, Y. Yazicioglu, T. J. Royston, and S. M. McCormick. “Effect of Vibro-Acoustic Stimuli and Shear Stress Alone and in Combination on Gene Expression.” Transactions of Biomedical Engineering Society, Nashville, TN (10/1 – 4, 2003, 9.P2.74).
Nanotechnology
Publications
·
Michael A. Stroscio, Mitra Dutta, Dinakar
Ramadurai, Peng Shi, Yang Li, Milana Vasudev, Dimitri Alexson, Babak Kohanpour,
Akil Sethuraman, Vikas Saini, Amit Raichura, Jianyong Yang. “Optical and
Electrical Properties of Colloidal Quantum Dots in Electrolytic Environments:
Using Biomolecular Links in Chemically-Directed Assembly of Quantum Dot
Networks”. Journal of Computational Electronics. Vol. 4, 2005, p 21-25.
·
Michael A. Stroscio, Mitra Dutta, Dinakar
Ramadurai, Peng Shi, Yang Li, Dimitri Alexson, Babak Kohanpour, Vikas Saini,
Amit Raichura, and Jianyong Yang. “Electrical
and Optical Properties of Colloidal Quantum Dots and Quantum Dot Networks: Role
of Surface States and Using Biomolecular Links in Network Assembly.”
Scientific and Technical Reports of NASA, Volume 43, Issue 13, (July 1, 2005)
20050177570.
· Michael A. Stroscio, Mitra Dutta, Peng Shi, Dinakar Ramadurai, Dimitri Alexson, Babak Kohanpour, Yang Li, Vikas Saini, Chen Chen, and Amit Raichura. “Nanoscale Colloidal Semiconductor Quantum Dots: Electrical and Optical Properties and Applications in Systems Integrated on the Terascale with Biomolecular Links.” 36th ACS Great Lakes Regional Meeting 2004, Peoria, IL (10/17-20, 2004, 280).
· Stroscio, M.A. Dutta, M. Ramadurai, D. Kohanpour, B. Alexson, D. Peng Shi Sethuraman, A. Yang Li Saini, V. “Tunable optical properties of colloidal quantum dots in electrolytic environments.” 10th International Workshop on Computational Electronics, (10/24 – 27, 2004, P02-33).
·
D. Ramadurai, B. Kohanpour, D. Alexson, P. Shi,
A. Sethuraman, Y. Li, V. Saini, M. Dutta and M. A. Stroscio. “Tunable
optical properties of colloidal quantum dots in electrolytic environments.”
IEE Proc Nanobiotechnol. Vol. 151, No. 6, December 2004, p 189-192.
· Mike Stroscio, M. Dutta, Babak Kohanpour, Dinakar Ramadurai, Dimitri Alexson, Peng Shi, Akil Sethuraman, Yang Li, and Vikas Saini, “Electrical and Optical Properties of Colloidal Quantum Dots: Role of Surface States.” 206th Electrochemical Society Meeting, Honolulu, October 2004, 1009.
· Mike Stroscio, M. Dutta, Dinakar Ramadurai, Peng Shi, Yang Li, Dimitri Alexson, Babak Kohanpour, Akil Sethuraman, Yang Li, Vikas Saini, and Jianyong Yang, “Electrical and Optical Properties of Colloidal Quantum Dots: Role of Surface States.” Army Science Conference, Florida, December 2004.
Book Chapter
· Michael A. Stroscio, Mitra Dutta, Dinakar Ramadurai, Peng Shi, Yang Li, Dimitri Alexson, Babak Kohanpour, Vikas Saini, Amit Raichura, and Jianyong Yang,“Electrical and Optical Properties of Colloidal Quantum Dots and Quantum Dot Networks: Role of Surface States and Using Biomolecular Links in Network Assembly,” in Nanoscale Devices, Materials, and Biological Systems: Fundamentals and Applications, Vol. PV-2004-13, edited by M. Cahay, D. Lockwood, J.P. Leburton, and S. Bandyopadhyay (Electrochemical Society Press, Jan 2004) ISBN: 156677456X.
Leadership
· Managed the second annual “Experience Bioengineering Summer Camp” in June 2002 for cell and tissue engineering. My work involved giving insight and training to high school students and teachers
· Presenting research findings in various major international research conferences
· Project management, training of undergraduate and graduate researchers in the laboratory
· Lab Chemical Safety Office, Radiation Safety Officer from 2001 to July 2006
Computer Skills
· Programming in C++, HTML, and MATLAB
· Microsoft Office, Canvas, Endnote, dChip, SigmaPlot, SigmaStat
Memberships
· Biomedical Engineering Society (BMES) Student member
· American Heart Association (AHA)
· Medical Council of India (MCI)
· American Association of Physicians of Indian Origin (AAPI)
Awards/Honors
· Student travel award for annual meeting of the Orthopedic Research Society 2006
· Student travel award for annual fall meeting of the Biomedical Engineering Society 2003
· National Merit Scholarship during 4 ½ years of Medical Studies